Archives

  • 2018-07
  • 2019-04
  • 2019-05
  • 2019-06
  • 2019-07
  • 2019-08
  • 2019-09
  • 2019-10
  • 2019-11
  • 2019-12
  • 2020-01
  • 2020-02
  • 2020-03
  • 2020-04
  • 2020-05
  • 2020-06
  • 2020-07
  • 2020-08
  • 2020-09
  • 2020-10
  • 2020-11
  • 2020-12
  • 2021-01
  • 2021-02
  • 2021-03
  • 2021-04
  • 2021-05
  • 2021-06
  • 2021-07
  • 2021-08
  • 2021-09
  • 2021-10
  • 2021-11
  • 2021-12
  • 2022-01
  • 2022-02
  • 2022-03
  • 2022-04
  • 2022-05
  • 2022-06
  • 2022-07
  • 2022-08
  • 2022-09
  • 2022-10
  • 2022-11
  • 2022-12
  • 2023-01
  • 2023-02
  • 2023-03
  • 2023-04
  • 2023-05
  • 2023-06
  • 2023-08
  • 2023-09
  • 2023-10
  • 2023-11
  • 2023-12
  • 2024-01
  • 2024-02
  • 2024-03
  • Level of CD and other blood parameters in

    2022-07-26

    Level of CD4 and other blood parameters in patients before and after intervention are presented in Table 2. The mean of the CD4+ level before treatment in the intervention and placebo groups was 161.5 ± 291.1 and 159.9 ± 337.4, respectively (P = 0.232), which increased after treatment in both groups to be 336.5 ± 155 (P = 0.045) and 246.5 ± 440.9 (P = 0.001). There was no significant difference between ALKP, ALT, AST, BUN, creatinine, white blood cells, AZ3146 sale and platelets in both intervention and placebo groups before and after treatment (P > 0.05).
    Discussion This study was conducted to determine the therapeutic effect of CoQ10 in HIV infected patients and the result of this study shows that auxiliary treatment with CoQ10 likewise placebo along with routine treatment improved the immune system's activity and increased CD4 + levels without affecting the hepatic function test and hematologic indexes. It should be noted that the demographic parameters, including the weight, were not significantly different between the two groups. In 2001, Batterhman et al. in Australia examined the effects of using antioxidants, including CoQ10, on viral load in 48 HIV infected patients who referred to outpatient clinics for treatment. A twelve week regimen full of high dose antioxidant was administered in half of these patients and the other patients received low dose antioxidant regimen and they concluded that such component increases oxidative defense parameters, but in viral load didn't change significantly which is somewhat similar to the present study. In 1978, in a study by Bliznak et al. in one of the colleges of California on mice show that the immune impairment was significantly associated with a decrease in CoQ10 levels and this effect was corrected by CoQ10 treatment. In 1982, Folker et al. studied 8 patients with chronic disease in Russia and administered CoQ10 for 27–98 days in these patients and an increase in serum immunoglobulin G level was observed in all patients and this result suggest that CoQ10 may have a role in the prevention and reversal of immune system deficiencies related to chronic disease. Folker et al. in another study reported that blood level of CoQ10 in HIV patients is lower than the general population, also, blood level of this concentration in patients with AIDS is less than asymptomatic HIV positive patients. They treated 6 AIDS patients with 200 mg CoQ10 daily, one patients excluded the study because, he didn't participate in follow up, but the other patients didn't show any evidence of opportunistic infectious after 4–7 months. Also, in 3 of these 6 patients T cell helper/suppressor increased and it was normalized in one patient. Folker et al. study show that reduction in CoQ10 level is common in HIV patients and CoQ10 supplement rise the immune level in HIV patients and decrease the opportunistic infections. Kitayama et al., in 2008 in Japan show that Macrophage infected HIV virus secrete a substance called VPR (viral protein R) that cause neural cells damage and suppress neural cells precursors, but, CoQ10 anchor this effect and can protect neural cell against VPR.
    Funding This work was supported by Ahvaz Jundishapur University of Medical Sciences.
    Availability of data and materials
    Authors' contributions
    Conflicting interests
    Acknowledgements