• Torin2: Next-Generation mTOR Inhibition for Mechanistic C...

  2025-10-16

  Discover how Torin2, a selective mTOR inhibitor, enables detailed, multi-layered dissection of mTOR signaling and protein kinase inhibition in cancer research. This article uniquely explores Torin2’s application in advanced apoptosis assays and transcription-coupled cell death, providing depth beyond standard reviews.

• br Materials and methods br

  2023-07-06

  

  Materials and methods Results Discussion Very few ARF inhibitors have been developed to study the key functions these small GTP-binding proteins play in pathophysiology. The natural compound Brefeldin A (BFA) has exhibited drastic effects in cells such as collapse of the Golgi because of it

• We have previously reported alterations of the

  2023-07-06

  

  We have previously reported alterations of the thymus in AChR-MG patients, especially in their germinal center Genomic DNA Isolation Kit (defined as CD19+CD38+ cells by flow cytometric analysis). First, we found that, in MG thymi, this subset failed to show the normal down-regulation of Bcl-2, sugg

• The first suggestions that the cleaved intracellular

  2023-07-06

  

  The first suggestions that the cleaved intracellular domain of APP, AICD, might transit to the nucleus and hence selectively regulate gene transcription arose from analogies with the Notch receptor signalling system where similar intra-membrane proteolysis occurs [84], [85] and it was later confirme

• Using our infection assays we

  2023-07-06

  

  Using our infection assays, we also explored whether low-pH compartments were required for the entry of ZIKVs in mammalian cells. Lysosomotropic agents such as ammonium chloride, chloroquine and Bafilomycin A1, strongly inhibited the ability of ZIKVs to enter mammalian cells. Our results are in agre

• The present study indicates elevated

  2023-07-06

  

  The present study indicates elevated ATX activity as a highly sensitive and specific biomarker to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. In Oltipraz to the current gold standard for diagnosis, total fasting serum bile salt levels, ATX appeared as a ve

• In the current study we

  2023-07-05

  

  In the current study, we showed that known inhibitors of the F-ATPase and ionophores affect the growth of P. gingivalis and its plasma membrane ATPase, suggesting that the membrane ATPase can be a target for anti-periodontitis agents. We also identified stilbenoids that strongly inhibit the growth o

• Protein phosphorylation is an important posttranslational me

  2023-07-05

  

  Protein phosphorylation is an important posttranslational mechanism for the regulation of distribution, trafficking, and function of modified proteins (Wang et al., 2014). GluA1 phosphorylation at S845 also has functional consequences (Lu and Roche, 2012). For instance, S845 phosphorylation drove tr

• There are profound differences between acute and chronic

  2023-07-05

  

  There are profound differences between acute and chronic pain when dramatic changes occur in peripheral nociceptors and central nociceptive pathways and the pain system is sensitised thereby leading to exaggerated responses to noxious stimuli (hyperalgesia) and responses to non-noxious stimuli (allo

• Recent progress has been made in translating animal

  2023-07-05

  

  Recent progress has been made in translating animal findings on memory performance and amnestic effects – that are largely determined by tonically active receptors in which α5 contributes to the benzodiazepine binding site. Based on the observation that deletion of this subunit led to improved spati

• br Conclusion br Introduction Breast cancer is the most comm

  2023-07-05

  

  Conclusion Introduction Breast cancer is the most common cancer and second leading cause of cancer-related deaths in women [1,2]. There were about 1.7 million new cases of breast cancer worldwide in 2012 [3], and the number of new cases of female breast cancer is expected to increase to 3.2 mi

• We made a number of choices

  2023-07-05

  

  We made a number of choices in the original design of our experiments. First, we used only portions of the 5′ and 3′ regulatory elements from S. cerevisiae. The sequences of these regions were known [32] and our goal was to express the Pf-DHFR at low levels. In fact, our choice of only 600 bp of the

• The initial demonstration of the

  2023-07-05

  

  The initial demonstration of the potential of MALDI-TOF MS for testing antifungal susceptibility of pathogenic fungi came from a proof-of-concept study by Marinach et al. [31] who monitored the changes of the proteome of C. albicans Tempol exposed to different concentrations of fluconazole. Using a

• Maynard et al demonstrated that serum levels of sFlt were

  2023-07-05

  

  Maynard et al. [54] demonstrated that serum levels of sFlt-1 were five times higher in pregnant women with PE than in normotensive women; as a consequence, VEGF and PlGF levels were found to be proportionally reduced in these women [54]. The literature confirms that there is a sharp increase in sFlt

• AR is expressed in cell specific human ovarian

  2023-07-05

  

  AR is expressed in cell-specific human ovarian follicles at all stages of follicular development [25]. Administration of androgens in animals demonstrated initiation of follicular recruitment, stimulation of early stages of follicular growth, and increase in the number of growing follicles [26,27].

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