• A recent novel and important finding is that YAP connects

  2022-08-24

  

  A recent novel and important finding is that YAP connects cellular growth with anabolism; YAP suppresses the transcriptional induction of genes which importantly regulate gluconeogenesis in the liver; namely glucose-6-phosphatase catalytic subunit (G6PC) and phosphoenolpyruvate carboxykinase 1 (PCK1

• Beckman Coulter s DxN VERIS

  2022-08-24

  

  Beckman Coulter’s DxN VERIS Molecular Diagnostics System (DxN VERIS System) is a fully automated system for the quantitative analysis of molecular targets, integrating sample introduction, nucleic Apramycin Sulfate extraction, reaction set-up, real-time PCR amplification and detection using TaqMan®

• br Materials and methods br Results br Discussion Serum

  2022-08-24

  

  Materials and methods Results Discussion Serum HBsAg is not only an important serological marker for the screening and diagnosis of HBV infection but also an important indicator for the treatment of hepatitis B [15]. Jaroszewicz et al. [4] and Nguyen et al. [8] reported that the HBsAg level

• CgtA is involved in stringent

  2022-08-24

  

  CgtA is involved in stringent response and it interacts with SpoT to maintain optimal (p)ppGpp/ppGpp quotient in bacteria. Depletion of CgtA results in increased ppGpp levels [8]. CgtA is also important for cellular development [12] and involved in synchronization of DNA replication initiation and c

• br Acknowledgments br Introduction Obesity

  2022-08-24

  

  Acknowledgments Introduction Obesity and type 2 diabetes (T2D) are two major chronic non-communicable diseases that are increasing worldwide at an alarming rate; the majority of people with T2D are overweight or obese, and T2D associated with obesity is expected to have doubled by 2030 (Chen e

• In order to elucidate the mechanisms behind the observed

  2022-08-24

  

  In order to elucidate the mechanisms behind the observed changes in metabolic activity in the cardiomyoblasts we investigated changes in gene and protein expression subsequent to treatment with PSN632408 with or without concurrent exposure to palmitate. Activating GPR119 in basal and high palmitate

• CD binding to gp causes a large scale

  2022-08-24

  

  CD4 binding to gp120 causes a large scale conformational change of gp120 which involves the gp120 core structure and the transitions of inner-domain layers (layer 1, 2 and 3), but also involves the movement of the major loops (V1, V2 and V3) [16], [17], [18], [19]. For instance, the V2-loop joins th

• br Reaction mechanism The dissimilarity between monofunction

  2022-08-24

  

  Reaction mechanism The dissimilarity between monofunctional and bifunctional glycosylases is that the monofunctional glycosylases removes the substrate base, leaving an intact AP site while the bifunctional glycosylases have an additional lyase activity. This intrinsic lyase activity is present i

• br Methods and materials br Results and discussion br

  2022-08-24

  

  Methods and materials Results and discussion Conclusions This is the first study that attempted to isolate, purify and identify the characteristics of GS-9137 from ginseng. In vitro studies have demonstrated that PGL-1 efficiently suppressed SH-SY5Y cell apoptosis induced by Aβ25–35, possi

• br Conflict of interest br Transparency document

  2022-08-23

  

  Conflict of interest Transparency document Acknowledgements We acknowledge our funding sources from the American Heart Association (13EIA4480016) and the National Institute of Health/National Heart, Lung, and Blood Institute (RO1 HL094414). We are very grateful to Dr. Shaohua Xiao and Dr. S

• Thus aldolase catalyzing the reversible reaction of

  2022-08-23

  

  Thus, aldolase catalyzing the reversible reaction of F1,6-P2 synthesis is involved in the formation of the glyconeogenic or glycolytic complex, dependently on the physiological state of the cell. In the process of glycogen synthesis, the enzyme not only supplies the substrate for FBPase and desensit

• Our results are consistent with the hypothesis that reduced

  2022-08-23

  

  Our results are consistent with the hypothesis that reduced Fas-mediated apoptosis in maternally activated T-lymphocytes could result in insufficient trophoblast invasion of the spiral Desfuroylceftiofur receptor as the activated T-lymphocytes become able to enhance the destruction of the cytotroph

• Histamine receptors were largely linked with allergic

  2022-08-22

  

  Histamine receptors were largely linked with allergic and inflammatory reactions before the recognition of the histamine H3R in 1983 that proved its function as auto- as well as heteroreceptor at pre- and postsynaptic membranes and demonstrated its intense regulating influence on release of numerous

• The newest histamine receptor to be

  2022-08-22

  

  The newest histamine receptor to be discovered is the H4 receptor, which was identified in humans and cloned in 2000 (Thurmond, 2010). Genetically, the H4 receptor is closely related to the H3 receptor, but is restricted to MLN120B within the spleen, intestines and thymus, and to immune cells such

• br Notch Similar to the Wnt and Hedgehog

  2022-08-22

  

  Notch Similar to the Wnt and Hedgehog pathways as discussed earlier, Notch is an evolutionarily conserved primordial developmental pathway which affects patterning, and has an important role to play in cancer biology ranging from angiogenesis to cancer stem ret pathway to tumor immunity [88]. No

15069 records 343/1005 page Previous Next First page 上5页 341342343344345 下5页 Last page