• Autophagy plays a multifaceted role in regulating both

  2022-08-18

  

  Autophagy plays a multifaceted role in regulating both the quality and quantity of protein (e.g., protein half-life and activity) and organelles (e.g., mitochondrial number and function), thus determining cell fate [15]. The induction of autophagy has been generally considered a programmed cell surv

• To evaluate the role of increased FPPS expression in paclita

  2022-08-18

  

  To evaluate the role of increased FPPS expression in paclitaxel-treated cells, we investigated the effects of FPPS on Orlistat progression. DNA content analysis showed that the number of cells accumulating in the G/M phase increased in a dose-dependent manner in paclitaxel-treated cells (A and B),

• It is known that microglial function

  2022-08-18

  

  It is known that microglial function and morphology are closely related [20], but no studies have addressed whether neuroinflammation induced by alcohol might modify microglial vandetanib (i.e. morphology, neuroimmunochemical phenotype) through an eCB-dependent mechanism. Since this alcohol-induced

• Our observation that glioblastoma tumor cells express ETA R

  2022-08-18

  

  Our observation that glioblastoma tumor cells express ETA-R in 6/10 cases contrasts with a recent publication reporting ETB-R expression in these tumors [17]. The reason for the discrepancy between that report and the present study might be due to the fact that glioblastomas with oligodendroglial co

• Intestinal epithelium renewal is tightly controlled

  2022-08-17

  

  Intestinal epithelium renewal is tightly controlled by Hedgehog genes. Three Hedgehog genes are highly conserved in mouse and human, including Sonic hedgehog (Shh), Indian hedgehog (Ihh), and Desert hedgehog (Dhh) [13]. Hedgehogs bind to Patched (PTCH) [[14], [15], [16]], which unlike conventional r

• FHPI Receptor guanylyl cyclases play essential roles in

  2022-08-17

  

  Receptor guanylyl cyclases play essential roles in cardiovascular and gastrointestinal (patho-)physiology, reproduction biology, cell proliferation, bone growth and sensory signal transduction and, therefore, are important pharmacological targets. Accordingly, the receptor guanylyl cyclase agonists

• Although some PAHs that are

  2022-08-17

  

  Although some PAHs that are human carcinogens have been found in the sugarcane soot (Zamperlini et al., 1997), there are no data about cancer incidence among sugarcane workers. To the best of our knowledge, this is the first report of an evaluation of internal exposure, comparing the harvesting (whe

• Two genes PATL and RASSF whose relationship to

  2022-08-17

  

  Two genes (PATL2 and RASSF1), whose relationship to HIV infection had not previously been reported, were identified in this study. Although PATL2 and RASSF1 have been implicated in cell division and tumor suppression, respectively (Scheller et al., 2007, Rather et al., 2014, Liu et al., 2002), their

• Type diabetes mellitus T DM causes

  2022-08-17

  

  Type 2 nmda (T2DM) causes vascular complications and is a major public health problem associated with lifestyle diseases such as obesity, liver steatosis, hypertension, and so on. Although serum lactate is reportedly elevated in diabetic patients [12], [13], the physiological effects remain unclear

• The hypothesis that genes involved in type diabetes evolved

  2022-08-17

  

  The hypothesis that genes involved in type 2 diabetes evolved under changing selective pressures and may carry the signature of natural selection motivated us to describe patterns of sequence variation at CAPN10 and GPR35 in human populations. An initial population genetics study reported an unusual

• As natural ligands of GPR several long chain polyunsaturated

  2022-08-17

  

  As natural ligands of GPR120, several long chain polyunsaturated fatty acids (Lc-PUFAs) have been demonstrated to modulate the 3T3-L1 adipogenic differentiation. However, the effects of the Lc-PUFAs are inconclusive. DHA is shown to inhibit, promote or even not affect the differentiation of preadipo

• Heparin Xie et al b reported that the combination of diagnos

  2022-08-17

  

  Xie et al. (2009b) reported that the combination of diagnostic ultrasound impulses and cyclic RGD-bearing MBs targeted for GP IIb/IIIa resulted in the successful recovery of epicardial and microvascular blood flow in swine models with acute thrombotic occlusion. It is well known that the stability o

• Although we showed that RBL H Sc

  2022-08-17

  

  Although we showed that RBL-2H3 Sc98 MPI-0479605 took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter family, including SE

• Transient forebrain ischemia in rodents induces a reduction

  2022-08-17

  

  Transient forebrain ischemia in rodents induces a reduction in expression of mRNA encoding the AMPA receptor subunit GluR265, 66, 67, 68, 69 (Fig. 3). gluR2 mRNA expression is markedly reduced in the CA1 region (the EW-7197 region most vulnerable to ischemia-induced damage), but not in the CA3 regi

• A significant contribution to the discovery of

  2022-08-17

  

  A significant contribution to the discovery of novel Hh inhibitors is given by natural compounds [11,17,22,31,32]. The first Hh inhibitor ever discovered has been Cyclopamine, a steroidal alkaloid isolated from plants of the Veratrum species [13,33]. Subsequently, many natural compounds belonging to

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