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Prostaglandins PGs in particular PGE and PGF play pivotal
2021-06-22
Prostaglandins (PGs), in particular PGE2 and PGF2α, play pivotal roles in human parturition by stimulating cervical ripening, myometrial contraction and fetal membrane rupture (Challis et al., 1997). In human pregnancy, the amnion is the principle source of PGE2 (Duchesne et al., 1978). In the amnio
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In summary we investigated the fluoride
2021-06-21
In summary, we investigated the fluoride sensitivity of different S. mutans strains in terms of enolase activity. Lower enolase activity was not always associated with lower S. mutans growth in cultures with NaF. Gene analysis showed that UA130 and NCH105 both have enolase point mutations. Unique am
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br Methods br Results br Discussion The
2021-06-21
Methods Results Discussion The findings of this study indicate that an ET system including ET-1 and ET-2 as well as ET receptors are present in the retina and RPE/choroid, and are up-regulated by both hypertension and diabetes. Specifically, individual antagonism of the ETRA or ETRB deliver
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br Acknowledgements The study of
2021-06-21
Acknowledgements The study of RING-type E3s continues to grow extremely rapidly. We regret that it was possible to only cite a fraction of the outstanding primary publications in this field. This work was supported by the National Institute of General Medical Sciences grants R01 GM088055 and R01
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Moreover in this study weak expression of
2021-06-21
Moreover, in this study, weak expression of MT1 and MT2 was also detected in the oviduct muscular layers. Although there are no reports regarding the role of MT1 and MT2 in oviduct muscular layers, previous studies have demonstrated that melatonin plays an important role in the uterine contractility
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br Restenosis after angioplasty remains a remarkable challen
2021-06-21
Restenosis after angioplasty remains a remarkable challenge, although drug-eluting stents have reduced the incidence of restenosis considerably . Vascular smooth muscle Ch 55 (VSMCs) play a pivotal role in the development of intimal thickening and restenosis. VSMCs proliferate and migrate from th
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XL184 The totality of evidence from randomized clinical tria
2021-06-21
The totality of evidence from randomized clinical trials supports the premise that worsening XL184 failure is a class effect of DPP-4 inhibitors. A meta-analysis by Verma et al. (54) of 100 randomized controlled clinical trials reported that the use of DPP-4 inhibitors was accompanied a significant
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Altogether these data suggested that GlmU might be
2021-06-21
Altogether these data suggested that GlmU might be involved in the M. smegmatis biofilm mediated defence mechanisms. GlmU belongs to a metabolic pathway leading to UDP-GlcNAc from fructose-1-phosphate involved in the biosynthesis of peptidoglycan and lipopolysaccharide (Fig. 8). Recently, we demonst
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We have performed our MSP analyses as real time PCR
2021-06-21
We have performed our MSP analyses as real-time PCR using SybrGreen (Fig. 2). The results of the beta-actin PCR vary in each sample group because the amount of DNA for bisulfite treatment was adjusted to a constant volume of serum (500μl) rather than to equal amounts of DNA. Because we expected lowe
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Allele specific methylation has been
2021-06-21
Allele-specific methylation has been observed in CpG islands of imprinted genes.27, 32 In the present study, however, methylation of CpG1 was specific to ALL [D-Lys3]-GHRP-6 and occurred in the leukemia cells of 28% of children with ALL, but it was not found in normal leukocytes from the same patie
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Many countries in all over the world generate
2021-06-21
Many countries in all over the world generate a large amount of RHA from uncontrolled and controlled burning. RHA is a pozzolanic material due to this high percentage of SiO2 in RHA. Rice husk ash, as a mineral additive, is produced by burning rice husks, which are obtained in the rice milling indus
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The development and activation of T
2021-06-19
The development and activation of T MAZ51 synthesis play an important role in the progression of atherosclerosis. As for activation and differentiation of T cells, TCR signalling pathway is pivotal. ZAP70 plays a crucial role in formulation of TCR–microclusters, initiation of TCR signalling pathway,
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Drug resistance to both pathogens and cancer has been
2021-06-19
Drug resistance to both pathogens and cancer has been a big hindrance in healthcare. Integrated research undertakings are being pursued to find the exact causes of the lack of response towards drugs. Surprisingly, host pumps are the key factors in failure of most drugs. The pumps either do not allow
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A comparative analysis of the cleavage activity of different
2021-06-19
A comparative analysis of the cleavage activity of different forms of the BoNT/A endopeptidase in reduced conditions with SNAPtide and full-length SNAP-25 substrate is summarized in Fig. 5, Fig. 6. The BoNT/A LC was found to be the most active against SNAPtide, a small peptide segment of the SNAP-25
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br Conclusion br Acknowledgment The authors would
2021-06-19
Conclusion Acknowledgment The authors would like to thank “Science and Engineering Research Board (SERB) of Department of Science and Technology (DST) Govt. of India” (Grant No.YSS/2015/002017) for funding the project. Introduction Mutations occurring within EGFR exons 18 to 21 are present
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