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perk kinase br Future directions There is increasing
2019-06-13
Future directions There is increasing evidence that osteoblasts are important components of the bone metastatic niche, but their precise contribution in supporting tumour cell engraftment, dormancy and survival remains to be defined. Unlike osteoclasts, the role of osteoblasts in bone metastasis
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Certainly dynamic interactions between DTCs and stromal cell
2019-06-13
Certainly, dynamic interactions between DTCs and stromal cannabinoid receptor within the bone microenvironment disrupt bone homeostasis, which is normally tightly controlled, to fuel metastatic progression [18] (Table 1). For example, it is well established that osteolytic breast cancer DTC-derived
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Las formas literarias de presentaci n de los textos aqu
2019-06-13
Las formas literarias de presentación de los textos aquí comentados son distintas: estamos frente a una obra de teatro, dos artículos (o capítulos de libro) y un cuento. El establecimiento de una ‘periodización’ de la historia de la literatura mexicana a partir de cuatro etapas —la prehispánica,
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Sin embargo m s all de
2019-06-13
Sin embargo, más allá de las coincidencias sobre qué hacer con y en el exilio, las significativas posiciones que se presentaron en sus páginas estuvieron lejos de mantener una posición unívoca. Como sugirió Gago, en Controversia pueden reconocerse al menos tres figuras: (1) el exilio como privilegio
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dacomitinib Accumulating literature has showed MSCs and HSCs
2019-06-12
Accumulating literature has showed MSCs and HSCs may be beneficial for CD patients. We searched all studies available to evaluate clinical efficacy and safety of stem dacomitinib in severe refractory CD. Located in bone marrow, HSCs can give rise to all blood cells and transplanted HSCs can reconst
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The mechanism leading to the gelatinous
2019-06-12
The mechanism leading to the gelatinous transformation may involve inhibition of tyrosine kinase activity by tyrosine kinase inhibitors (TKI) leading to blockage of downstream signal pathways, affecting extracellular matrix deposition, adipocyte differentiation and angiogenesis. Moreover, the catabo
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Baseline WBC count and baseline
2019-06-12
Baseline WBC count and baseline measures of hepatic and renal function for responders and nonresponders are shown in Table 1. No relationship was evident between responders to decitabine or treatment choice and baseline WBC counts, or between responders and baseline measures of hepatic function (ALT
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Recently a reciprocal fusion between YPEL yippee like and PP
2019-06-12
Recently, a reciprocal fusion between YPEL5 (yippee-like 5) and PPP1CB (serine/threonine protein phosphatase-1 beta catalytic subunit) was described to be exclusively expressed in more than 90% of primary CLL samples [5] and not in control samples or samples from patients with other hematological ma
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African leaders are gathering in Addis Ababa Ethiopia this
2019-06-12
African leaders are gathering in Addis Ababa, Ethiopia, this week for the first ever . The event brings together government officials, including minsters of finance, technical experts, and policymakers, with the goal of advancing the coverage of life-saving immunisations across the continent. In
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br Role of ICD treatment In
2019-06-12
Role of ICD treatment In patients with VT associated with various structural igf1r inhibitor diseases, ICD therapy is recommended even if the target VT is successfully ablated and no VT is inducible after catheter ablation [29]. This is because, in such patients, the same VT and/or new VT recurs
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Based on the methodology used in previous studies the
2019-06-12
Based on the methodology used in previous studies, the EGM source for the Wavelet algorithm has been nominally programmed as the Can-RV coil EGM [13]. As the nominal EGM source includes the generator, myopotentials induced due to body motion or other muscle activity are likely to influence the arrhy
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The benign exostoses in TRPS have
2019-06-12
The benign exostoses in TRPS have a recognized malignant potential which have been shown to develop into chondrosarcomas [4,13]. Both our index case and his mother demonstrated de novo high grade osteosarcoma. To our knowledge, this occurrence has not been described anywhere within the literature.
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At least genes are associated with familial LQTS
2019-06-12
At least 15 genes are associated with familial LQTS, with 3 of these genes accounting for 70–75% of cases [5]. Despite advances in the understanding of the molecular basis of LQTS, challenges remain in making the clinical diagnosis. Importantly, between 10–40% of gene carriers have normal QT interva
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De todas maneras no escapa a la tem tica de
2019-06-12
De todas maneras no escapa a la temática de este trabajo la intuición de un contradictorio hecho: de que en este intento de interpretación de estos dos polémicos capítulos de Paradiso, dionisíacos, lo que estamos haciendo es, una vez más, buscar la sistematización iluminista, apolínea, a la que el m
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However during pacing at the most
2019-06-11
However, during pacing at the most proximal CS electrodes (CS 9–10), although the conduction time to the CS 1–2 was prolonged, the septal to lateral activation sequence (CS 5–6 to CS 3–4 to CS 1–2) indicated the presence of residual conduction on the MI line (Fig. 3B). Detailed mapping on the MI lin
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