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br Antifungal resistance what is in
2023-04-18
Antifungal resistance, what is in a name? Antifungal resistance is an emerging and hot topic in the field of medical mycology. Microbiological resistance is identified by determining minimal inhibitory concentrations (MICs) in vitro for a given antifungal and interpreting this value according to
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br Acknowledgments This work was supported by
2023-04-17
Acknowledgments This work was supported by grants from the “Agence Nationale de la Recherche” ANR-09-CESA-006 program, the Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (Anses, Project n° 2012-2-077) and the Interdisciplinary Program “Longévité et Viei
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In a recent issue of
2023-04-17
In a recent issue of , Minokoshi and colleagues have added more light to our understanding of the role of hypothalamic AMPK in the regulation of energy balance. Previous seminal work from the same group suggested that AMPK in the PVH might be involved in the modulation of feeding . Here, they show
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Recently Kamoshita et al evaluated a mouse
2023-04-17
Recently, Kamoshita et al. (2016) evaluated a mouse model of retinal neuronal disturbance with the intraperitoneal injection of LPS and found that treatment with AICAR suppressed the reduction of conical function and decreased mRNA levels of TNF-α as well as improved mRNA levels of the mitochondrial
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The reactions and the control mechanisms described
2023-04-17
The reactions and the control mechanisms described are all supported by observations. For example the reactions require that different compounds are formed in different groups of nos inhibitor cells and this has been observed [15]. Intravenous injection of glycine results in reduced utilisation of
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br Concluding Remarks and Future Perspectives While
2023-04-17
Concluding Remarks and Future Perspectives While postmortem human Angiotensin 1/2 (1-5) synthesis material is relatively sparse and has inherent limitations as discussed above, additional investigations could benefit from analysis of in vitro cellular models to corroborate findings in patient ma
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Recently rather than predicting categorical variables as
2023-04-17
Recently, rather than predicting categorical variables as in classification, several studies begin to estimate continuous clinical variables from Parathyroid hormone (1-34) (human) australia images. Therefore, instead of classify a subject into binary or multiple pre-determined categories or stages
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br Study approval br Author contributions br
2023-04-17
Study approval Author contributions Conflicts of interest Acknowledgements This work was supported by grants of the Youth Backbone Program (to Jianming Ying) of Cancer Hospital, CAMS, Beijing, Beijing Hope Run Special Fund of Cancer Foundation of China (LC2015A06) and the National Natura
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Previous studies have demonstrated the presence
2023-04-17
Previous studies have demonstrated the presence of soluble NTPDases, 5′-nucleotidase and adenosine deaminase in rat blood serum as well as in human blood (Doleski et al., 2016; Oses et al., 2004; Yegutkin, 1997; Yegutkin et al., 2007). In addition, our earlier reports have shown that these membrane-
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Introduction Dementia is a common disease in the
2023-04-17
Introduction Dementia is a common disease in the elderly, and a significant source of disability, healthcare spending, and long-term care admissions. There is evidence to suggest that testosterone plays a role in cognitive functioning, and lower serum levels correlate with higher amyloid deposits (
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In considering the roles of
2023-04-17
In considering the roles of these enzymes in normal physiology, given the importance of GLUT4-dependent glucose uptake and glucose-dependent fatty chir99021 synthesis for systemic metabolic homeostasis (Herman and Kahn, 2006, Herman et al., 2012), deletion of Acly in adipocytes results in a surprisi
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NO is an important mediator for
2023-04-17
NO is an important mediator for maintaining bone integrity since it plays a role in the bone remodeling process. It was shown that mechanical strain and shear stress induce NO synthesis in osteoblasts and osteocytes (van't Hof & Stuart, 2001). It was reported that mechanical loading influences its a
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RS 127445 HCl br The role of apelin in hypertension
2023-04-17
The role of apelin in hypertension diseases The role of apelin and its receptor APJ in cardiovascular diseases has been described in numerous studies (Table 2) [36,37]. It has been revealed that exogenous apelin may lower blood pressure. Tatemoto et al. [6] have discovered that different forms of
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br Introduction The term antioxidant derives
2023-04-17
Introduction The term antioxidant derives from the prevention of the oxygen consumption. In the late of 19th centuries, antioxidants were generally used in industrial processes such as against to metal corrosion, vulcanization of rubber. Later on, the use of antioxidants to prevent the rancidity
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We designed SSOs that block APP exon
2023-04-14
We designed SSOs that block APP exon 17 splicing and induce the production of an alternatively spliced APP mRNA lacking exon 17 (APPΔex17). APPΔex17 mRNA encodes an APP protein isoform that lacks 49 Sildenafil mesylate including the γ-secretase cleavage sites that give rise to the toxic, AD-associa
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