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Due to the importance of gene regulation in
2022-09-08
Due to the importance of gene regulation in cancers, HDAC inhibitors have been studied extensively in cancer biology and are in current clinical use as anti-tumor therapies [17]. The HDAC inhibitors vorinostat, romidepsin, and belinostat have been approved for certain T-cell lymphomas, and panobino
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Mortality from breast cancer is almost always attributed to
2022-09-08
Mortality from breast cancer is almost always attributed to metastatic spread of the disease to other organs, thus precluding resection as a treatment method. Unfortunately, conventional chemotherapy fails to eradicate most human cancers, including aggressive breast cancers. Studies over the past de
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Studies utilising GPR mice however
2022-09-08
Studies utilising GPR55−/− mice, however, report different effects of GPR55 on body weight and insulin sensitivity. Genetic deletion of GPR55 appears to have no effect on overall body weight 5, 6, 7. However, one of these studies found increased fat deposition and insulin resistance in GPR55−/− mice
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Among prostaglandins PG PGD remained the most elusive specie
2022-09-08
Among prostaglandins (PG), PGD2 remained the most elusive species for a long time and was initially regarded as having negligible biological activity [1]. In 1974 its inhibitory effect on platelet aggregation was discovered by Smith et al. [2] and Mills & McFarlain [3], and both pressor and depresso
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br Methods br Results br Discussion br Conclusion The
2022-09-08
Methods Results Discussion Conclusion The in vivo pEC50 for NEFA release in the rat was derived for 12 GPR81/GPR109A agonists, including the historically well-known nicotinic acid. By integrating in vitro cell assay potency data for both receptors, these in vivo pEC50 values could be rea
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br Introduction Over the past two decades the
2022-09-08
Introduction Over the past two decades, the prevalence of obesity and obesity-associated metabolic diseases, such as T2D, insulin resistance, atherosclerosis and stroke, have been dramatically increased globally [1], [2], and obesity has been suggested to be the leading cause of the reduced life
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br Ligand binding free energies In order
2022-09-07
Ligand-binding free energies In order to compute the absolute free moxalactam associated with binding a ligand to a flexible iGluR LBD, a theory that accounts for all the principal thermodynamic contributions from ligand docking and LBD closure had to be developed. This was accomplished using an
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The neurobiological mechanisms underlying DHK induced NOR le
2022-09-07
The neurobiological mechanisms underlying DHK-induced NOR learning and memory impairments remain unclear. Accumulated evidence shows that astrocyte-neuron lactate shuttle is of crucial important in synaptic plasticity and memory formation, and regulation of neuronal gene expression related to synapt
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In order to discover novel small molecule compounds with the
2022-09-07
In order to discover novel small-molecule compounds with the activity of GLUT4 translocation, we conducted a cell-based phenotype screening in L6-GLUT4-myc myoblasts by measuring appearance of GLUT4 on the plasma membrane (GLUT4 translocation activity). Evaluation of total 183,400 compounds gave sev
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Ghrelin receptors in non mammals are
2022-09-07
Ghrelin receptors in non-mammals are reportedly more “complicated/complex and diverse” than in mammals, having additional paralogs and splice variants (Kaiya et al., 2014). Several teleost fish GHS-Rs have been identified; however, functional characterization has been conducted in only a few (see, K
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Therefore as it stands presenilin has a secretase independen
2022-09-07
Therefore as it stands, presenilin has a γ-secretase-independent role in regulating protein trafficking, proteolysis and degradation, however given that inhibition of γ-secretase activity can have a negative effect on protein trafficking [69], [98], we cannot exclude the possibility that some of the
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br Conflict of interest br Acknowledgment
2022-09-07
Conflict of interest Acknowledgment M.D.P. lab is supported by the EPFL and Swiss National Science Foundation (SNF grant No. 200020_157153). Introduction As amyloid-β peptide (Aβ) accumulation in the crizotinib mg starts in the very early stages of Alzheimer’s disease (AD) pathology (Bate
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If the manager channel dominates we expect
2022-09-07
If the manager channel dominates, we expect the increase in debt maturity of treated firms relative to control firms to be more evident in firms with weaker corporate governance where managers are less monitored and have more discretion in changing firm risks. We use the governance index (GINDEX) co
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The Rho family of GTPases is composed of many small
2022-09-07
The Rho family of GTPases is composed of many small ubiquitous signaling G proteins that bind to guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). They act as switches: when binding to GTP, they are active and associate with a variety of target proteins that regulate intr
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3146 The primary cancer lesion was mostly in
2022-09-07
The primary cancer lesion was mostly in the uterus and adnexa, followed by the gastrointestinal tract, brain, blood, and kidney and 3146 (Fig. 2A). Histopathological findings indicated that most cancers were adenocarcinomas, followed by squamous cell carcinomas, glioblastomas, malignant lymphomas,
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