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br Introduction br Results br
2022-06-07
Introduction Results Discussion Experimental Acknowledgment Introduction Endocannabinoids, N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) have been found in most mammalian tissues and they stimulate cannabinoid CB1 and CB2 receptor activity thereby modulating se
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Furthermore the immunoassays described in our study
2022-06-07
Furthermore, the immunoassays described in our study showed excellent concordance of more than 93.33% with the LAg-Avidity EIA (Table 2). Using a panel of samples obtained from HIV-1 seroconverters over the course of up to 602 days post-infection, the gp41 peptide-based MP3 or MP4 assay identified s
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Alamethicin The histamine H receptor H R
2022-06-07
The histamine H3 receptor (H3R; 326–445 amino-acids) is located on histaminergic neuron somata, dendrites and axon varicosities, as well as on the axon varicosities and somata of other neurons, providing negative feedback to inhibit histamine synthesis and the release of histamine or other transmitt
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Another level of complexity within
2022-06-07
Another level of complexity within the TGF-ß/SMAD and Hippo/YAP/TAZ pathway crosstalks was recently uncovered. TGF-ß induces robust TAZ, but not YAP, protein expression in both mesenchymal and epithelial proton pump inhibitors list through a SMAD3-independent, p38/MAPK-dependent mechanism that trig
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In addition to lifestyle factors genetic factors may
2022-06-07
In addition to lifestyle factors, genetic factors may also influence the efficacy of antineoplastic drugs in breast cancer patients.16, 17 The HER2 gene contains several single nucleotide polymorphisms (SNPs). Two of the most investigated HER2 SNPs are Ile655Val (rs1136201) and Ala1170Pro (rs1058808
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br Hedgehog in chronic liver disease The liver responds to
2022-06-07
Hedgehog in chronic liver disease The liver responds to different chronic insults with a highly conserved wound healing response during which different cell types must communicate to reconstruct fully functional, healthy liver parenchyma. The inter-cellular dialogue that orchestrates effective li
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The therapeutic potential of acetate has been advocated by r
2022-06-07
The therapeutic potential of acetate has been advocated by research on neurodegenerative disorders such as Canavan's disease (Arun et al., 2010, Mathew et al., 2005), where oral acetate improved motor function in a genetic model of the disorder, and in studies of behavioural phenotypes associated wi
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It was speculated that could
2022-06-07
It was speculated that could affect the protein translation or processing in the HCV replication cycle. The viral protein processing was thus investigated, to establish whether the HCV inhibition was determining an increased amount of unprocessed polyprotein, due to a block in the processing, or a
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We found few differential effects on lung function
2022-06-07
We found few differential effects on lung function for exposure to mother’s and father’s smoking in relation to GSTM1 and GSTT1. However, effects related to mother’s or father’s smoking may differ because mothers tend to spend greater amounts of time with young children and mothers may also smoke du
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br Other Functions of HCA Receptors HCA receptors in particu
2022-06-07
Other Functions of HCA Receptors HCA receptors, in particular HCA1, are expressed in various primary tumor Ginsenoside Rd 77, 78, 79. This is of interest, as most solid tumors show increased glucose uptake and lactate formation even under normoxic conditions, with lactate concentrations in the t
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One previously unreported discovery is that Ptgds
2022-06-07
One previously unreported discovery is that Ptgds is alternatively spliced, such that partial removal of exon 3 correlates with higher levels of regeneration. The absence of exon 3 likely affects the functionality of the final product. The structure of Ptgds is that of the typical lipocalin β-barrel
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The calculations for the R substrate
2022-06-06
The calculations for the R substrate showed that, like the S substrate, the coordination shell of the Zn (R)-PFI 2 hydrochloride is more symmetric than in the HIC-SG crystal structure. This symmetry indicates that the enzyme could use the same reaction mechanisms as for the S substrate, but with ex
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During the structural transition the
2022-06-06
During the structural transition, the FD, the PHD and the TrD retain their tertiary structure. Nevertheless, they undergo large rearrangements in their relative orientation due to secondary changes in hinge segments (R1 to R5) which refold during the low-pH induced conformational change. Particularl
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br Materials and methods br Conflicts of interest
2022-06-06
Materials and methods Conflicts of interest Some of the peptidomimetic compounds in this work are the subject of the patent application “Peptidomimetics for Imaging the Ghrelin Receptor”, WO/2016/191865 A1, December 8th, 2016. Acknowledgements Special thanks go to Rebecca McGirr (Lawson He
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br Materials and methods br Results br Discussion
2022-06-06
Materials and methods Results Discussion Prior studies established that Notch signaling regulates the differentiation of hair cells and supporting cells during inner ear development (reviewed in Kiernan (2013)). Notch signaling is a multistep process that requires the interaction between a
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