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Having shown that some of substitutions Cl CF
2021-11-12
Having shown that some of substitutions (Cl, CF) at the 2-position of the thiophene improved rat microsomal stability, and polar groups at the 4-position of the aryl ring had a beneficial effect on stability in both human and rat microsomes, we combined these features in a new set of analogs. Methyl
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The rapid actions of glucocorticoids range from the producti
2021-11-12
The rapid actions of glucocorticoids range from the production of endocannabinoid as a retrograde messenger [9], to regulation of ion channels [10], [11], to inhibitory effects on immune iMDK [12], [13], [14]. Many different kinase signaling pathways have been implicated in the rapid actions of glu
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br Preclinical development of GIP agonists Since the action
2021-11-12
Preclinical development of GIP agonists Since the action of DPP IV is not limited to GIP, the most specific pharmacological approach for GIP would be modification at the N-terminus to disrupt DPP IV-mediated degradation. Indeed, it has been shown that GIP analogues with N-terminal modifications a
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To improve the performance of the immunoassay
2021-11-12
To improve the performance of the immunoassay, various nanomaterials including carbon nanospheres [9], gold nanoparticles [10] and transition metal compounds [11] were used to immobilize natural enzymes as the label. Natural enzymes, such as horseradish peroxidase (HRP) [12] and glucose oxidase (GOD
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br Conflicts of interest br Acknowledgment br Introduction T
2021-11-12
Conflicts of interest Acknowledgment Introduction The (S)-(+)-Dimethindene maleate growth factor receptors (FGFRs) are a family members of receptor tyrosine kinase (RTK) that represent attractive therapeutic targets for anti-cancer therapy gaining more and more attention in recent years [1
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All of the abovementioned effects
2021-11-12
All of the abovementioned effects of PUFAs signal their involvement in a cellular phenotype switching phenomenon, which is increasingly recognized as a potential target for future pharmacotherapies of atherosclerosis, especially for individuals who do not respond to the classical lipid-lowering stra
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Immunohistochemistry using anti FFAR antibodies
2021-11-12
Immunohistochemistry using anti-FFAR1 antibodies revealed immunoreactivity for FFAR1 in association with the cell membrane of the hepatocytes (Figure 2). However, the anti-FFAR2 antibody was not suitable for immunohistochemistry under the tested conditions (data not shown). Fatty liver is an import
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WT associated protein WTAP a nuclear protein
2021-11-12
WT1 associated protein (WTAP), a nuclear protein, is first identified by Little [6] who noticed its specific interaction with WT1. Besides several essential physiological processes, such as mRNA stabilization [7], eye development [8], m6A methylation [9], mRNA alternative splicing [10] and AN-2728
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Recent findings of us suggest that compounds that inhibit
2021-11-12
Recent findings of us suggest that compounds that inhibit both FAAH and TRPV1 may be more efficacious in pain relief than those targeting only one such protein. As continuation of our efforts to identify new molecules able to target simultaneously both FAAH and TRPV1 receptors, we hypothesized that
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br HO and cerebral malaria
2021-11-12
HO-1 and cerebral malaria In a post-mortem evaluation of human cerebral (falciparum) malaria, strong HO-1 immunostaining was consistently noted in microglia/macrophages within and surrounding the pathognomonic Durck’s granulomas (Schluesener et al., 2001). As witnessed in cerebral trauma specimen
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FoxM a downstream target of Gli has been mainly related
2021-11-12
FoxM1, a downstream target of Gli, has been mainly related to Desfuroylceftiofur sale regulation and cellular proliferation in tumor (Alvarez-Fernandez and Medema, 2013, Halasi and Gartel, 2013, Teh et al., 2002). Especially, FoxM1 is a regulator of G1/S and G2/M transitions and M-phase progression
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In the present study we focused on a role of
2021-11-11
In the present study, we focused on a role of the C-terminal segment in GCAP2 using two chimeric proteins, in which the C-terminal segment of GCAP2 was either replaced by the corresponding sequence of recoverin (chimera GR) or transferred into recoverin (chimera RG). We have monitored Ca-dependent c
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Enzyme parameters obtained for GC E variants can
2021-11-11
Enzyme parameters obtained for GC-E variants can further be introduced in kinetic models of phototransduction using computational approaches. A similar approach has been successfully applied in the investigation of disease causing mutations of GCAP1 to simulate rod and cone photoresponses under dise
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br Discussion Regulation of redox homeostasis
2021-11-11
Discussion Regulation of redox homeostasis is critical in the maintenance of normal cell functions, and both glutathione S-transferase and peroxiredoxin enzymes are important contributors to this process. There are numerous reports of aberrant expression patterns of GSTP linked with cancer and wi
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We suggest that the FRET enhancement observed when the
2021-11-11
We suggest that the FRET enhancement observed when the modified mD1 protein containing Acd at position 28 was excited at 260nm (), may differ from the diminution in fluorescence observed following excitation at 280nm due to the excitation of different transitions in Trp (i.e., the L and L transition
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