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In conclusion the most salient observation
2021-09-16
In conclusion, the most salient observation from this study was that PAE reduced the expression of HDC protein expression in dentate gyrus, cerebral cortex, and cerebellum, but not in the caudate nucleus or ventral hypothalamus. The regional basis for this heightened sensitivity is not known, but it
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As a measure of ROS
2021-09-16
As a measure of ROS formation we measured the extent by which Cu(I) affected the production of hydrogen peroxide and, at the same time, to ensure that there would not be shortage of NADH substrate. Our results show that H2O2 production is increased over time by LPS stimulation but it is not when mic
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PNU 37883 hydrochloride The activation of AKT and
2021-09-16
The activation of AKT and ERK1/2 results in the stabilization and increase in the co-transcriptional function of β-catenin [31], [32], [33]. Here, (R,R′)-MNF was found to reduce the levels of phospho-active AKT and ERK, which, in turn, may regulate the abundance and signaling potential of β-catenin.
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Here we report the first attempts to
2021-09-16
Here we report the first attempts to assess roles of NTs and ABC transporters in transfer of ribavirin across the placental barrier using human placental villous fragments and microvillous plasma membrane (MVM) vesicles, in situ dually perfused rat term placenta, and cell-based models. Materials
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Solasodine Finally it is possible that the increase
2021-09-16
Finally, it is possible that the increase in the number of EAAT-3-labelled cells in the DG at PD 60, when compared with the control and experimental animals at PD 14, is associated with natural changes in the number of neurons present during the postnatal development of the hippocampus (41, 42) and,
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ll-37 br Methods br Results and discussion Protein analysis
2021-09-16
Methods Results and discussion Protein analysis of commonly used cell lines (C6, D54-MG, U87, U251 and STTG1) reveals high ll-37 of SXC (Cho and Bannai, 1990, Ye et al., 1999, de Groot et al., 2005, Lyons et al., 2007, Savaskan et al., 2008). Since protein expression can be altered over time
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br Materials and methods br Results br
2021-09-16
Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast Disulfiram receptor by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity of GLUT1 occurs within
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Deregulation of HH signaling pathway in epidermal keratinocy
2021-09-16
Deregulation of HH signaling pathway in epidermal keratinocytes is a primary event leading to the formation of BCC (see above). Overexpression of SHH in HaCaT keratinocytes grown in organotypic cultures induces a basal cell phenotype and increases invasiveness. This behavior is linked to increased E
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br GJs in the brain br Alterations of
2021-09-15
GJs in the brain Alterations of GJs in epilepsy The role of GJ blockers and openers in epilepsy As previously known, GJ-mediated electrical coupling plays a role in the generation of highly synchronous electrical activity. The hypersynchronous neuronal activity is a significant feature of c
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br Conflicts of interest br Acknowledgements This research w
2021-09-15
Conflicts of interest Acknowledgements This research was supported by grants from National Research Foundation, Korea (NRF-2017RIDIA3B04033313) and Yeungnam University (216-A-061-042). Introduction Kluyveromyces lactis is a yeast that produces one of the ß-galactosidases (ß-gals) most wide
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br Rationale The present study was motivated to get
2021-09-15
Rationale The present study was motivated to get further insight into the molecular recognition processes of 2-alkyl(amino)ethyl-1,1-bisphosphonates taking compounds 12–14 as reference structures. We have recently demonstrated that TcFPPS inhibitors 12 and 13 bind to the allylic site of the enzym
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Chemotherapeutic approaches to glioblastoma which
2021-09-15
Chemotherapeutic approaches to glioblastoma, which are highly invasive, are still largely unsuccessful and have only a minimal impact on patients’ survival rate . New agents that target the specific molecular aberrations in the tumors are presently being investigated for their efficacy against this
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Several observations about structure activity relationships
2021-09-15
Several observations about structure–activity relationships can be made from this series, including that: (1) all lead compounds are NSAIDs of the 2-arylpropionic cytochalasin d class, (2) analogues with -oriented aryl substituents showed the best inhibition of FAAH, and (3) replacing the ether link
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Dysregulation of the HPA axis resulting
2021-09-15
Dysregulation of the HPA axis, resulting in alteration to both baseline and stress-induced glucocorticoid levels (e.g., cortisol and corticosterone), has been implicated in several diseases and psychopathologies, including anxiety (McEwen et al., 2015, 2016; Shin and Liberzon, 2010). For example, ba
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Two recently developed highly specific
2021-09-15
Two recently developed, highly specific EZH2 enzymatic inhibitors, GSK126 and EPZ-6438, are currently in clinical trials for treating lymphomas (Kim and Roberts, 2016). Although these EZH2 inhibitors have shown antitumor effects in lymphoma cells with enzyme-activating mutations of EZH2 (Knutson et
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