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Treatment related adverse events have been a serious issue i
2021-06-22
Treatment-related adverse events have been a serious issue in clinical application. Severe toxicity has been reported in clinical trials using antibody blockade of CSF-1R (20 mg/kg), PD-1, and CTLA-4.29, 30, 31 However, apparent side effects were not observed in our study with PLX3397 treatment alon
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The molecular mechanism by which CRM regulates IEC apoptosis
2021-06-22
The molecular mechanism by which CRM1 regulates IEC apoptosis in CD remains to be explored. As an inhibitor of cyclin E-Cdk2, p27kip1 plays a pivotal role in controlling cell proliferation, S phase entry, and G1 phase exit during development and tumorigenesis [38]. As previously reported, p27kip1 is
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plk1 inhibitor The significant CRF increase in the DS and
2021-06-22
The significant CRF increase in the DS and the overall changes in the CRF system observed in the VM and DS during the development of sensitization suggest that this neuropeptide (and possibly urocortin) contributes to the specific molecular alterations occurring in the mesolimbic pathway that suppor
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The importance of mitochondria as site of aerobic
2021-06-22
The importance of mitochondria as site of aerobic oxidation of metabolic fuels, such as FA, has been recognized for a long time. It has been observed that the number of mitochondria may vary in response to cellular metabolic requirements and hormonal environment (Gao et al., 2014). In order to susta
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br Thermodynamic modeling br Selection of data The solutes w
2021-06-22
Thermodynamic modeling Selection of data The solutes were selected based on the set of data needed to evaluate the CPA-EoS for prediction of their solubility in CO2 + cosolvent, as shown in Fig. 1. Critical temperatures, melting temperatures and enthalpies of fusion of the solutes are required
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740 Y-P br Acknowledgements This work was supported in part
2021-06-22
Acknowledgements This work was supported in part by JSPS KAKENHI Grant Number 26292031. Introduction The Cys-loop receptors constitute an important superfamily of ligand-gated ion 740 Y-P (LGICs) and mediate synaptic transmission in both invertebrate and vertebrate nervous systems (Jones et a
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Not all of the biological activities exhibited by progestoge
2021-06-22
Not all of the biological activities exhibited by progestogens (Table 1) are mediated via binding to SRs. For example, the anti-estrogenic action of progestogens in the BMS 753 mg is due to the progestogen-bound PR suppressing ER gene expression, and consequently the ability of the cell to respond t
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br The interaction network between the lncRNAs which have be
2021-06-22
The interaction network between the lncRNAs which have been obtained from the previous steps, VDR and ESR was depicted using Cytoscape tool. Moreover, LncMAP tool (Li et al., 2018) was used to show transcriptional regulatory effects of two lncRNAs (MALAT1 and TBX5-AS1). The interaction network dep
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Prostaglandins PGs in particular PGE and PGF play pivotal
2021-06-22
Prostaglandins (PGs), in particular PGE2 and PGF2α, play pivotal roles in human parturition by stimulating cervical ripening, myometrial contraction and fetal membrane rupture (Challis et al., 1997). In human pregnancy, the amnion is the principle source of PGE2 (Duchesne et al., 1978). In the amnio
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In summary we investigated the fluoride
2021-06-21
In summary, we investigated the fluoride sensitivity of different S. mutans strains in terms of enolase activity. Lower enolase activity was not always associated with lower S. mutans growth in cultures with NaF. Gene analysis showed that UA130 and NCH105 both have enolase point mutations. Unique am
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br Methods br Results br Discussion The
2021-06-21
Methods Results Discussion The findings of this study indicate that an ET system including ET-1 and ET-2 as well as ET receptors are present in the retina and RPE/choroid, and are up-regulated by both hypertension and diabetes. Specifically, individual antagonism of the ETRA or ETRB deliver
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br Acknowledgements The study of
2021-06-21
Acknowledgements The study of RING-type E3s continues to grow extremely rapidly. We regret that it was possible to only cite a fraction of the outstanding primary publications in this field. This work was supported by the National Institute of General Medical Sciences grants R01 GM088055 and R01
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Moreover in this study weak expression of
2021-06-21
Moreover, in this study, weak expression of MT1 and MT2 was also detected in the oviduct muscular layers. Although there are no reports regarding the role of MT1 and MT2 in oviduct muscular layers, previous studies have demonstrated that melatonin plays an important role in the uterine contractility
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br Restenosis after angioplasty remains a remarkable challen
2021-06-21
Restenosis after angioplasty remains a remarkable challenge, although drug-eluting stents have reduced the incidence of restenosis considerably . Vascular smooth muscle Ch 55 (VSMCs) play a pivotal role in the development of intimal thickening and restenosis. VSMCs proliferate and migrate from th
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XL184 The totality of evidence from randomized clinical tria
2021-06-21
The totality of evidence from randomized clinical trials supports the premise that worsening XL184 failure is a class effect of DPP-4 inhibitors. A meta-analysis by Verma et al. (54) of 100 randomized controlled clinical trials reported that the use of DPP-4 inhibitors was accompanied a significant
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