Archives
- 2018-07
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
-
br Genetic analysis of polarity complexes Model organisms su
2023-12-11
Genetic analysis of polarity complexes Model organisms such as Caenorhabditis elegans and Drosophila melanogaster provide useful means of describing basic biological processes. They lend themselves particularly well to addressing some of the questions arising in this field because of their struct
-
br Future directions outlook Peptide based macrocycles are a
2023-12-11
Future directions-outlook Peptide-based macrocycles are among the privileged scaffolds in antibiotic drug discovery. Many compounds were discovered by natural product screening and developed unchanged, or as semi-synthetic derivatizations. Since the golden age of antibiotic discovery (1940s-mid 1
-
br Angiogenesis as a critical event in
2023-12-11
Angiogenesis as a critical event in diabetic retinopathy Angiogenesis refers to the abnormal proliferation of blood vessels during various pathological conditions. It acquires the stature of being one of the most detrimental events responsible for the progression of diabetic retinopathy. Angiogen
-
Under some pathological conditions AT R internalization is
2023-12-11
Under some pathological conditions, AT1R internalization is decreased when agonist exposure is prolonged. This weakens or removes the AT1R desensitization effect and leads to AT1R and downstream signal overactivation. AT1R overactivation can result in continued biological effects such as sustained v
-
br The prevalence of diabetes is increasing
2023-12-11
The prevalence of diabetes is increasing globally, and the situation is particularly alarming in Asia. The prevalence of diabetes in China has increased dramatically, from around 1% in 1980 to the most recent estimate of 9.7% according to a nationwide survey . Cumulative evidence shows that type 2
-
LDC1267 br Disclosure br Acknowledgments br Introduction
2023-12-11
Disclosure Acknowledgments Introduction Deeper understanding of the pathobiology of non-small cell lung cancer (NSCLC) has led to the development of small LDC1267 that target genetic mutations known to play critical roles in the progression to metastatic disease. Mutations in epidermal gro
-
DCG IV br Detection and possible treatments for prostate can
2023-12-11
Detection and possible treatments for prostate cancer PC can be diagnosed, by screening for prostate-specific antigen (PSA) and after diagnosis, treatments may include intense observation, radical prostatectomy, radiation, chemotherapy, hormone therapy or vaccination depending on the type and sta
-
In eukaryotes class III ACs including GCs
2023-12-08
In eukaryotes, class III ACs (including GCs) are almost universally present, with the noteworthy exception of higher plants. Our dataset comprises 9690 sequences of class III nucleotide cyclases from 710 eukaryotic species. Approximately 80% thereof belong to subclass IIIa and 10% to subclasses IIIb
-
br Concluding remarks ROP is
2023-12-08
Concluding remarks ROP is a major cause of childhood blindness in the world. Current pharmacological therapy focus on anti-VEGF strategy, but this strategy is associated with the unintended effects on delayed eye growth and retinal vasculature development of preterm infants. Preclinical studies u
-
Control of retinal vascularization during development and OI
2023-12-08
Control of retinal vascularization during development and OIR likely involves close interactions among endothelial cells, neurons and glial N1-Methylpseudouridine sale (microglial and astrocytes) (see Fig. 2). In particular, the interaction between endothelial tip cells and astrocytes plays a critic
-
br Materials and methods br Results br Discussions Diabetes
2023-12-08
Materials and methods Results Discussions Diabetes is mainly divided into Type 1 diabetes and Type 2 diabetes [16]. Type 2 diabetes, featured by insulin resistance, results from environmental factors and poor eating habits [2]. Type 2 diabetes accounts for more than 95% of the diabetic pati
-
We also investigated the transmittance of
2023-12-08
We also investigated the transmittance of actin polymerized with and without ABP. The presence of actin in the solution results in an increment in turbidity as other proteins provided BI-7273 features [21], [32]. While G-actin showed a transmittance peak positioned at 241 nm, F-actin exhibited a sma
-
In vitro studies with soman inhibited non aged
2023-12-08
In vitro studies with soman-inhibited, non-aged AChE revealed a species dependent reactivating potency of HI-6 and MMB-4. With guinea pig AChE second order reactivation rate constants of 0.051 and 0.038mM−1min−1 were determined for HI-6 and MMB-4, respectively (Luo et al., 2007). Corresponding value
-
Concerning asthma in a study
2023-12-08
Concerning asthma, in a study evaluating the effect of tiotropium in severe asthma, the sputum eosinophil count and exhaled nitric oxide were also assessed. However, evaluation of the anti-inflammatory effect of tiotropium was difficult because these markers were low at baseline and thereafter. In a
-
br Conflict of interest statement br
2023-12-08
Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal SR 57227 hydrochloride mg in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within thes
13048 records 64/870 page Previous Next First page 上5页 6162636465 下5页 Last page